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Amitriptyline
Clinical data
Pronunciation/ ˌ æ m ɪ ˈ t r ɪ p t ɪ l iː n / [1]
Trade namesElavil, others
AHFS/Drugs.comMonograph
MedlinePlusa682388
License dataUS   FDA: Amitriptyline
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, intramuscular injection
Drug classTricyclic antidepressant (TCA)
ATC codeN06AA09 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability30–60%
Protein binding96% [2]
MetabolismLiver [2] (CYP2C9)
Metabolitesnortriptyline
Elimination half-life10–50 hours [2]
ExcretionUrine [2]

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